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Chemotherapeutics causing CIPN likely have direct toxic effects on axonsevidenced by a lack of effect on axon integrity when applied to neuronal cell bodies under compartmentalized culturing conditions (Yang et al., 2009)although indirect effects due to altered gene expression cannot be ruled out

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Cold reduces blood flow to the injury, which helps reduce swelling and inflammation

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Importantly, OCTN1-mediated transport allows EGT to concentrate within mitochondria and other metabolically active cellular compartments where ROS generation is prominent