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A few commenters encouraged CMS to use the most recent data available to determine the appropriate payment for Mental Health (MH) and Substance Use Disorder (SUD) services to address workforce shortages

Abbreviations 17-HSD: 17-Hydroxysteroid dehydrogenase 3-HSD: 3-Hydroxysteroid dehydrogenase 3' UTR: 3' Untranslated region AMPK: AMP-activated protein kinase ATP: Adenosine 5'-triphosphate AR: Acrosome reaction ARE: Antioxidant Response Element ART: Assisted reproductive technologies ASAs: Antisperm antibodies BaP: Benzo--pyrene BER: Base excision repair CAT: Catalase Cdks: Cyclin-dependent kinases CKIs: Cdk inhibitors COX-2: Cyclooxygenase-2 CYP11A1: Cytochrome P450 Family 11 Subfamily A Member 1 DDR: DNA damage response Dpp: Days postpartum FSH: Follicle-stimulating hormone GPER: G protein-coupled estrogen receptor GSH-Px: Glutathione peroxidase GSDMD: Gasdermin D GSK-3: Glycogen synthase kinase-3 hCG: Human chorionic gonadotropin HIF-1: Hypoxia-inducible factor 1-alpha HO-1: Heme Oxygenase-1 HPG: Hypothalamic-pituitarygonadal HRR: Homologous recombination repair HSD17B3: Hydroxysteroid 17-beta dehydrogenase 3 HS: Heat stress IDH2: Isocitrate dehydrogenase 2 ILs: Interleukins iNOS: Inducible nitric oxide synthase LPO: Lipid peroxidation LH: Luteinizing hormone MDA: Malondialdehyde Mfn2: Mitofusin 2 mPTP: Mitochondrial permeability transition pores NER: Nucleotide excision repair NLCs: Nanostructured lipid carriers NLRP3: NOD-like receptor pyrin domain-containing 3 Nrf2: Nuclear Factor Erythroid 2-Related Factor 2 OXPHOS: Oxidative phosphorylation P4: Progesterone PGCs: Primordial germ cells PGE2: Prostaglandin E2 PD: Polydatin RCTs: Randomized controlled trials ROS: Reactive oxygen species RSV: Resveratrol SIRT1: Sirtuin 1 SOD: Superoxide dismutase STAR: Steroidogenic acute regulatory protein TNF-: Tumor necrosis factor- VEGF: Vascular endothelial growth factor m: Mitochondrial membrane potential References Brannigan RE, et al

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