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Description

Its complex pathogenesis involves dopaminergic neuron degeneration, -synuclein aggregation, neuroinflammation, oxidative stress, and mitochondrial dysfunction

Under conditions of cellular energy stress, the AMP/ATP ratio increases, activating AMPK through a dual mechanism involving allosteric activation and phosphorylation of the Thr172 site by upstream kinases such as LKB1 and CaMKK (Yang C

What evidence suggests that acetyl-L-carnitine might be an effective treatment for alcohol use disorder

Two strategies may be useful to move the field forward

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