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11,12 Substituting specific histone variants into the nucleosome can therefore alter the nucleosome structure and its interaction with DNA, resulting in changes to chromatin and higher order chromatin architecture

Generation of CHCHD2 knockout cells U87vIII CHCHD2 KO cells were derived using CRISPR-Cas9 genome engineering following published protocols [26]

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Daarnaast hebben sommige mensen van nature een betere of minder goede aanmaak van glutathion door genetische variatie