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Although it has been reported that disease phenotype only presents in tissues such as muscle and brain at high mutant loads (typically above 90%) for most pathogenic mutations, the MTND5 gene mutation can result in diseased phenotype at low mutant loads even below 50% (Kirby et al., 2003)

This indicates that viral infection of a particular cell might have pleiotropic effects on non-infected bystander cells, making them more permissive to viral replication

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What is the recommended dosing protocol when you stack MOTS-c 5-Amino-1MQ