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Second, when YopJ, a Yersinia effector protein, inhibited the activity of TGF--activated kinase-1 (TAK1) or IKK kinase, it activated the RIPK1-Caspase-8 pathway, leading to the cleavage of GSDMD and accelerated the occurrence of pyroptosis (Sarhan et al., 2018)

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Arch Neurol 67(6):731738 Matsuda N, Kitami T, Suzuki T, Mizuno Y, Hattori N, Tanaka K (2006) Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro

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For example, the inflammatory response can be prolonged by a failure of neutrophils to undergo apoptosis, of macrophages to clear apoptotic neutrophils, and/or by deficiency of other factors that promote ingestion of apoptotic cells by macrophages (Nathan and Ding 2010)