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1 Introduction Copper is an essential micronutrient that is critical for the maintenance of normal physiological functions

The iron-loaded transferrin is then recognized by the cell membrane receptor TfR1 and translocated into endosomes via the receptor-mediated endocytosis pathway, where ferric ions are released from the transferrin in acidic endosomes and then reduced to Fe 2+ by the enzyme prostate 3 metal reductase (STEAP 3) (71)

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