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Evidence from NAC Supplementation Studies Currently, researchers are looking to preliminary studies on NAC to justify ongoing clinical trials of glutathione supplementation because NAC is converted to glutathione in the body

[Confidence: Medium] Context / Source Open access Paper: Metabolic cross-feeding of a dietary antioxidant enhances anaerobic energy metabolism by human gut bacteria., August 13, 2025 Authors / Institution: Zhe Zhou, Angela Jiang, Xiaofang Jiang, Stavroula K

Clinical laboratory trials have shown that SFN is very well tolerated, and no serious adverse effect was observed except in rare cases of insomnia, irritability, and impaired tolerance to taste and smell (92)