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It is generally well-tolerated

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429 Conversely, inhibitory phosphorylation by TAK1, MAP kinase-activated protein kinase 2 (MAPKAPK2), IKK/ (at Ser320/Ser321, Ser336, and Ser25), and ULK1 (at Ser357) restrains RIPK1-mediated cell death, 430 suggesting residue-specific modulation of these targets