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Dimethyl fumarate, an FDA-approved treatment for MS, exerts neuroprotection by alleviating inflammation, oxidative stress, and ferroptosis through the NRF2/ARE/NF-B signaling pathway, thereby ameliorating cognitive impairments in chronic cerebral hypoperfusion in rats [199]

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When normalized to microdomain-specific maxima, HyPer7 similarly responded to exogenous H 2 O 2 treatment where the EC 50 in each compartment ranged between 1 to 2 M H 2 O 2 with sharp saturation beyond 2.5 M (Fig