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Furthermore, some limitations derived of treatment resistance to targeted therapies against glutamine metabolism have been reported

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Given that mitochondrial autophagy provides beneficial regulatory effects through low insulin signaling, increased insulin/IGF signaling can induce mitochondrial autophagy in certain types of tumors, thereby inhibiting tumor progression

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Mice were randomly assigned to control, 2.0% DSS (model), 2.0% DSS+SAPA (200 mg/kg, positive control), 2.0% DSS + SAC high dose (SAC, 200 g/kg) and 2.0% DSS + SAC low dose (SAC-L, 100 g/kg) groups