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Isso especialmente importante em situaes de insuficincia renal, cardiopatias, dislipidemias ou uso de medicamento especfico

VR: Writing original draft

Effect of polymorphism of (AC)n in the 5-end of aldose reductase gene on eryth-rocyte aldose reductase activity in patients with type 2 diabetes mellitus

In light of the recent findings that melatonin combined with conventional anti-cancer therapy could limit the adverse effect of chemotherapy and increase its therapeutic efficacy, including reducing drug resistance [159,160,161,162,166,167], its simultaneous use with DNMT inhibitors or other epigenetic drugs may be a more efficient approach to avoid the limitations of epigenetic drugs