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10.1152/ajpgi.00223.2019 76

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Keywords Salicylate Toxicology Source: aspirin or your local willow tree Mechanism of Action: Salicylates cause an uncoupling of oxidative phosphorylation Catabolism occurs secondary to the inhibition of ATP-dependent reactions with the following results: increased oxygen consumption,increased carbon dioxide production, accelerated activity of the glycolytic and lipolytic pathways, depletion of hepatic glycogen,hyperpyrexia Dosages: The usual daily dosage range for aspirin is two regular strength aspirin tablets (325 mg x 2 = 650 mg) every 4 hours (or 12 tablets/day)

(Expert Opinion) Other Treatments The Panel identified the treatments reviewed below as possibly prom ising but for which insufficient evidence currently exists to support even a Conditional Recommendation for their use

D63.1 is Anemia in chronic kidney disease and requires a CKD code sequenced first