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These changes temporarily disrupt the brain and blood flow signals involved in sexual response

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For example, repeated cortisone injections can weaken tendon structure and encourage the progression of tendon pathology from tendonitis to full tears

70 As a result, STAT3-dependent ZIP6 expression leads to downstream activation of the transcriptional repressor Snail, which contributes to the epithelial-mesenchymal transition (EMT) during embryonic development and is associated with tumor metastasis mechanisms (Fig