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This has a hexameric (6-copy) structure built from right-handed 4-helix bundles, each containing N-terminal hooks that chelate a Ni ion

Lauterburg BH, Adams JD, Mitchell JR: Hepatic glutahione homeostasis in the rat: efflux accounts for glutathione turnover

Decitabine up-regulates the expression of GSDME by inhibiting DNA methylation, and then causes pyroptosis of cancer cells and induces anti-tumor immunity of melanoma and TNBC [82, 83]