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Direct causal links between specific Ca 2+ dynamics and macrophage fate outcomes, such as phagocytosis efficiency, intramacrophage bacterial killing, or apoptosis resistance, are largely absent in Klebsiella infection, with existing studies confined to mouse models and lacking human THP-1/PBMC validation, which is needed for clinical translation

Similarly, "leaky gut" (increased intestinal permeability) can allow undigested food particles and bacterial toxins to pass into the bloodstream, potentially leading to systemic inflammation and indirect contributions to malodor

Ferroptosis synergistic immunotherapy efficacy in vivo HMPB-HKN 15 -based exo- and endogenous ferroptosis synergistic immunotherapy and related mechanisms are discussed in detail in vitro

W.LiuY.et al

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