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Description

Heat-killed Saccharomyces boulardii alleviates dextran sulfate sodium-induced ulcerative colitis by restoring the intestinal barrier, reducing inflammation, and modulating the gut microbiota

P., Materials Today Chemistry , 2018 , 10 , 221

In the pre- and post-subgroups, pooled studies were not homogenous ( 2 P = .004, I 2 = 82%)

In the pivotal, phase 3, placebo-controlled RESPONSE trial (NCT04620733), seladelpar, a novel delpar (selective PPAR-delta agonist), led to a significantly higher percentage of PBC patients achieving the composite biochemical endpoint (ALP 0 U/L from baseline) and safety by baseline ALP subgroup were also evaluated