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Hoffmann, J., et al

Also, the significance of this peptide's therapeutic benefit against amplified and advanced paracetamol toxicity remains to be further postulated, particularly considering the extensive investigation of gastrointestinal peptides in gastrointestinal and liver physiology (38), physiological mediators in NSAIDs-induced impairment of gastric mucosal defense and adaptation (39), and brain-gut peptide regulation (40)

Subdermal application overcomes this barrier and directly reaches the deeper layers of the skin, resulting in higher absorption and efficacy

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Effective for superficial skin concerns but limited systemic distribution