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The study was performed in accordance with the Declaration of Helsinki and approved by the Huashan Hospital Institutional Review Board, Fudan University (approval ID, No.2017-222)

Finally, putative metabolites with high confidence annotations were categorized using the ontology-based ClassyFire Batch Compound Classification web platform ( Data was normalized using a robust Progenesis QI TM built-in approach designed explicitly for untargeted metabolomics 62,63,68

Their tunable surfaces also allow for selective functionalization to target microbial virulence pathways rather than causing broad-spectrum killing, an approach that aligns with microbiome-sensitive therapy [74]

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