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NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs

This study revealed that mice administered with capmatinib along with anti-PD-1 exhibited extended survival rates compared to those given either capmatinib or anti-PD-1 alone