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Tat also mobilizes Ca 2+ from IP3-sensitive stores and activates novel PKC isoforms, enhancing TNF- production across macrophages, neurons, and astrocytes [97, 98]

8f, g) in Drd2 flox/flox mice

3.2.3 Phylum Proteobacteria As a key component of the gut microbiome predominantly composed of Gram-negative bacteria, increased Proteobacteria abundance is closely associated with epithelial barrier dysfunction and elevated intestinal permeability (Heckmann et al., 2025)

Cisplatin also affects calcium signaling pathways and the function of several protein kinase families, including the MAPK (mitogen activated protein kinases), JNK (c-Jun N-terminal kinase o), PKC (protein kinase C) and AKT (serine/threonine kinases) leading to cell death (Dasari and Tchounwou, A unique feature of oxaliplatin is its rapid non-enzymatic transformation to the reactive dichloro 1,2-diaminocyclohexyl-platinum complex and oxalate which occurs via replacement of the oxalate moiety with chloride ions in the blood plasma