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10.1073/pnas.2021073118 45 PeiZ.FlexederC.FuertesE.ThieringE.KoletzkoB.CramerC.et al (2013)

Following are at most risk: Vegans are at most risk of B-12 deficiency

Whilst the intrinsic factor-mediated absorption pathway can only process approximately 1.52 micrograms of B12 at a time, passive diffusion allows absorption of about 1% of higher doses

As a result, oxidative stress is considered a key factor in the decline of brain function and the progression of conditions like Alzheimers and Parkinsons diseases