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In the present study, we clearly demonstrated that long-term HFD consumption decreased hepatic NF-B activity

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CRP binds and aggregates oxidized low-density lipoprotein (ox-LDL) and enhances macrophage oxLDL uptake, promoting mitogen-activated protein kinase activation (171) required for foam cell formation (172)

However, the kinetics of superoxide radical removal by SOD mimetic compounds is much less effective than by SOD enzymes