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Another approach involves modifying Lactobacillus plantarum to produce native GLP-1, which was shown to improve metabolic parameters, reduce inflammation, and restore -cell function in HFD/STZ mouse models of T2DM (Hu et al., 2023)

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These transformations are mediated by a variety of colonic bacteria, including Clostridium spp., Flavonifractor plautii , and Eubacterium ramulus ( in vitro fecal fermentation model, Roowi et al

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The multivariate COX regression analysis showed that the advanced Nakanuma stage was confirmed as independent factor associated with the development of complications in patients with PBC