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Insulin resistance also lowers the synthesis of hepatic sex hormone-binding globulin (SHBG), further increasing free androgen levels (Song and Choi, 2022)

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In addition to downregulation of injury and inflammation-related pathways, GSEA also revealed suppression of adipogenesis-related pathways in the liver of GPR146-deficient mice, suggesting that GPR146 may promote hepatic steatosis via PPAR-mediated transcriptional programs (Fig

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

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