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As ART alone is insufficient to fully suppress HIV-1 replication, including the transcription and translation of the HIV-1 provirus, there is a critical need to develop new brain-penetrat agents that can effectively target both the CNS and the peripheral immune system to silence HIV-1 and reduce the risk of neuroinflammation

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Oxidativer Stress frdert die Bildung toxischer Proteinaggregate, wie Beta-Amyloid (bei Alzheimer) und Alpha-Synuclein (bei Parkinson) (7)

It is a multifactorial disease where genetic predisposition is central

Therefore, post-transcriptional regulation of gene expression by estrogen modifies the cellular proteome and phenotype at all levels of protein processing