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This landmark study demonstrates the capacity of purposeful engineering and rational development to build a capsid selection platform for the creation of novel, brain-targeted AAV gene transfer systems

Furthermore, while 4-HNE promotes cyst growth via multiple kinase pathways (270), the hierarchical integration of these pathways (e.g., which is the rate-limiting step) and their crosstalk with ferroptosis core networks (e.g., lipid peroxidation amplification) are poorly defined