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Out of 20 patients, 14 were homozygous for the R72 variant, five were heterozygous for the P72 variant and one patient was homozygous for the P72 variant

Adipocyte-, hepatocyte-, and muscle-derived histohormones act through autocrine, paracrine, and endocrine routes

The mammalian forked box transcription factor Class O (Foxo) family includes Foxo3, which functions as a downstream transcriptional factor in the AMPK signaling pathway and plays a crucial role in regulating antioxidant defenses and the autophagy process (179181)

Zhang QH, Zu XY, Cao RX, Liu JH, Mo ZC, Zeng Y, Li YB, Xiong SL, Liu X, Liao DF, Yi GH

Obesity: They are used as an adjunct to a reduced-calorie diet and increased physical activity to help promote weight loss in adults with a body mass index (BMI) of 30 or higher, or in adults with a BMI of 27 or higher who have at least one weight-related comorbidity, such as high blood pressure, type 2 diabetes, or high cholesterol