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Neurosci Lett 297:97100

For example, Tregs can express lymphotoxin (LT) 12, which activates LT receptors (LTRs) on tumor cells and lymphatic endothelial cells, triggering noncanonical NF-B signaling to promote tumor growth and lymphatic metastasis

J.BarrS

DMF inhibits GPX4 activity by reducing the GSH/GSSG ratio and forms a positive feedback loop with 5-LOX, which synergistically increases lipid peroxidation levels by 35 times and significantly induces tumor cell death