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Polt R, Porreca F, Szabo LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ

Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification

Subsequently, the cells were incubated with primary antibody (1:200) at 4 C for 15 h, followed by five washes with PBS

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Studies indicate that exposure to PS-NPs significantly downregulates dopamine levels in zebrafish (Ren et al., 2024), mechanistically linked to MPs-triggered neuroinflammation that inhibits tyrosine hydroxylase, a key enzyme in dopamine synthesis (Wang et al., 2025)