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13 Better understanding of the complex pathophysiology and underlying pathophysiological mechanisms of migraine may improve treatment options

They comprehend all off-label preparations, being, respectively an antiviral, an anti-spastic, and an anti-narcolepsy drug, and bearing numerous contraindications and side effects (e.g., heart, liver, and kidney damage as well as a potential teratogenic effect for amantadine) (Jensen et al., 2014