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Studies reviewed by Hector and Burton involving 91 patients with hypovitaminosis B12 who exhibited neuropsychiatric symptoms found that clinical improvement was achieved in many individuals through vitamin B12 replacement therapy (74)

Animal studies have revealed embryofetal toxicity at supratherapeutic doses

ApInAPDB ( is a recently established database composed of about 850 apoptosis-inducing peptides and their analogues provided from previous literature, including peptides binding target or binding affinity, function, and their effectiveness reported as IC50

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In terms of the occurrence of Hhcy in patients with -TM based on their MTHFR genotypes, the data show a significant and clear connection between Hhcy and possession of the MTHFR TT genotype, with all patients with the TT genotype (100%) being assessed hyperhomocystinemic (15 mol/l) compared to those with CT (40%) or CC genotypes (29%) P (Fig