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doi: 10.1105/tpc.110.079269 18 Fuentes-UgarteNPereira-SilvaMCortes-RubilarIVallejos-BaccelliereGGuixVCastro-FernandezV

Phenomic studies on diseases: Potential and challenges

doi: 10.1016/j.rbmo.2023.103319 [DOI] [PubMed] [Google Scholar] 130

The execution of ferroptosis involves complex regulation of multiple metabolic pathways (Figure 1), including disruptions in iron homeostasis, abnormalities in amino acid antioxidant systems, and the accumulation of lipid peroxides (Zheng et al., 2025

It also causes the formation of proteins needed for clotting, vasoconstriction, and cellular adhesion.[ref] This all adds up to inflammation in the blood vessels, higher blood pressure, and cardiovascular disease