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Phase II Trial of Infusional Fluorouracil, Irinotecan, and Bevacizumab for Metastatic Colorectal Cancer: Efficacy and Circulating Angiogenic Biomarkers Associated With Therapeutic Resistance

18 The therapeutic action of these stem cells is thought to be derived from their proangiogenic capacity that alters the cycle of vascular injury, ischaemia, and fibrosis characteristic of the inflammatory phase of PD

In oxidative stress and LPO environments, this process heightens the susceptibility to inflammation-driven cell death [343]

Epitope orientation sensitivity: if protective efficacy depends on conformationally constrained or spatially directional epitopes, orientation-defined systems (e.g., enzymatic ligation or SpyTag-mediated docking) are mandatory

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