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Biguanides (metformin): Medications used to treat type 2 diabetes, metabolic syndrome, nonalcoholic fatty liver disease, and polycystic ovary syndrome can lead to decreased vitamin B12 absorption (5)

Understanding its adverse effects is vital for safe and effective treatment

One theory is that vitamin B12 deficiency may trigger an autoimmune response in the joints, leading to inflammation and joint destruction associated with RA

During the 1990s and early 2000s, research interest increased in peptide fragments capable of interacting with cellular signalling systems and molecular regulatory pathways