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Description

J Appl Physiol

Extensive preclinical studies of NPI-001 support a strong mechanistic rationale for its use in RP, in which oxidative stress plays a known role

found that in the mouse mode heme oxygenase 1 (HMOX-1), heat induced and regulated by early growth response factor 1 (EGR1), can mediate ferroptosis in KCs and cause liver injury [47]