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-hydroxybutyrate becomes a metabolic decoy that feeds normal tissues and lymphocytes while starving the tumor 383 , an idea first articulated by Sidney Weinhouse, the opponent of the metabolic theory of cancer 300,301 , and elaborated in modern ketogenic-diet studies 25

28 This results from upregulation of GABA receptors and downregulation of dopamine receptors

& Bogorad, L

However, the lack of information about their binding site made optimization of these fragments difficult, which contrasts to the set of fragments disclosed in this work