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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Nguyen D., Deng P., Matthews E.A., Kims D.S., Feng G., Dickenson A.H., Xu Z.C., Luo Z.D

Identification and characterization of a novel snat2 (slc38a2) inhibitor reveals synergy with glucose transport inhibition in cancer cells

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Mechanistically, SSP intermediates couple to the TCA cycle, where PSAT1 catalyzes the conversion of 3-PHP to PS while simultaneously converting GLU to -KG, thereby channeling GLU-derived carbon into the TCA flux (58)