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After binding of oxygen, the molecule switches from T, which has a low affinity for oxygen, to R state which has high oxygen affinity (56)

Numerous studies in animal models submitted to infection and trauma (Reference Cruzat, Pantaleao and Donato7,Reference Cruzat, Bittencourt and Scomazzon9) , as well as critically ill and post-surgery (Reference Wang, Wu and Zheng29) patients, have demonstrated that exogenous administration of glutamine (both enteral and parenteral nutrition), significantly enhances the GSH system, increasing cellular resistance to lesions and reducing oxidative stress (Reference Cruzat, Macedo Rogero and Noel Keane4,Reference Smedberg and Wernerman30)

Science 266 , 294298 (1994)

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Symptom Overview Damage to motor, sensory, or autonomic nerves secondary to antineoplastic chemotherapy can result in varying degrees of dysfunction and/or pain, which can lead to significant morbidity and diminished quality of life for affected patients, with up to 70% of patients having some element of chemotherapy-induced peripheral neuropathy (CIPN) after chemotherapy