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Reference: Kaiqiang Sun, Jiuyi Sun, Chen Yan, et

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Fatty Acids When anionic lipids (Figure 87) are formulated into LNPs, they can interact with cationic lipids to form ion pairs, which can improve the pH-sensitivity of the LNPs and promote endosomal membrane destabilization, thus increasing nucleic acids delivery efficiency

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Furthermore, in both diseases, this accumulation of lipids has been associated with ER stress and mitochondrial dysfunction, ultimately resulting in cell damage and death (Figure 1) [100]