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By early morning, when the sun begins to lighten up our day, our pineal gland cuts back on melatonin production, telling our body to wake up and be ready for a new day

Brain 131 , 10871098 (2008)

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Metabolically linked exhaustion in CD8 + Tc during severe SARS-CoV-2 infection Given that metabolism is a critical regulator of immune cell function 43 , we next examined the functional characteristics of CD8 + Tc during COVID-19