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10.1074/jbc.M101266200 55 KaurK.SalomonR

Reactive Oxygen Species (ROS) are increased by the consumption of sugars and oxidized vegetable oils, smoking, alcohol, exposure to environmental toxins, high or chronic emotional stress, circadian rhythm dysregulation (poor sleep), lack of exercise, infections, and a lack of antioxidant intake

Such imbalances indicate a disruption of vaginal microecology ( Gardnerella vaginalis and Atopobium vaginae, which are indicative of dysbiotic vaginal microbiota, leads to the destruction of epithelial cell integrity and stimulates the release of pro-inflammatory factors by local immune cells ( Sneathia sanguinegens ( Lactobacillus -dominated microbiota expands

J Pharmacol Exp Ther 2006

In vitro, BPC-157 promotes fibroblast migration, angiogenesis, and nitric oxide (NO) pathway modulation, supporting endothelial cell survival and wound repair