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With more severe injury, synapse disruption, axonal injury, excitotoxicity, and cell death also become major effectors

Thioredoxin and glutaredoxin systems as potential targets for the development of new treatments in Friedreichs ataxia

Bruno and colleagues (2013) found reduced Glx in the caudate nucleus of patients with FXS [121], but Pan et al

cDNA was then used as template for RT-qPCR with a QuantStudio 3 Real-Time PCR system (Applied Biosystems) using PowerUP SYBR Green Master Mix (Applied Biosystems) and 500 nM of target gene specific forward and reverse primers, using the recommended fast cycling mode

Real-time qRT-PCR Real-Time qRT-PCR was conducted as described previously 46