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To ascertain hypoxic culture conditions, we used a standard color assay (viz., methylene blue reduction) 35

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35 Teunisse, S., Bollen, A

Loss of BMAL1 enhances nuclear factor kappa-light-chain-enhancer of activated b cells (NF-B) activation and prolongs inflammatory gene transcription in both macrophages and renal epithelial cells ( In the kidney, circadian misalignmentinduced by altered light-dark cycles or genetic manipulationleads to increased macrophage infiltration, tubular injury, and glomerular inflammation