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Some studies suggest that supraphysiologic doses shift the collagen ratio toward type III, a weaker form associated with immature or healing tissue

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Some clinicians prescribe split dosing with one administration in the morning (often ipamorelin alone) and the combined dose at bedtime, depending on the patients goals and response patterns

Responders displayed greater gut microbial alpha diversity (Inverse Simpson, p=0.0007) at baseline, as well as increased beta diversity (p=0.028) after their first FMT

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