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One of the widely tested drugs is Bexarotene, which is an RXR/LXR agonist that initially showed promising results in animal models of AD, increasing amyloid clearance and improving behavioral deficits [208, 209]

Subsequently, German internist Arnold Cahn (1858-1927) and German physician and physiologist Josef Freiher von Mering (1849-1908), working in the Strassburg clinic of German physician Adolf Kubmaul (1822-1902), showed that a patient with pernicious anemia had no hydrochloric acid in the stomach contents, a finding later demonstrated to be pervasive in this disorder and to precede the development of anemia (139)