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9% use it for 45+ days[] These safe therapeutic doses can significantly deplete glutathione in women who already have low baseline levels.[] Healthy individuals can tolerate up to 4g/day with only modest glutathione decrease, but individuals with compromised glutathione experience significant depletion even at therapeutic doses

Additionally, increased SEPT9 methylation levels, particularly in plasma samples from CC patients with pelvic nodal metastasis, underscored its potential application as a non-invasive prognostic biomarker [215]

Even mild elevations in plasma homocysteine levels increased the risk of stroke

Another PubMed review highlights the regenerative and protective actions of GHK-Cu, including gene regulation relevant to skin repair, wound healing, and cell-protective pathways

It's a very interesting experiment in social empathy