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Insulin-sensitizing peptides warrant caution given Retatrutides glucose effects

The combination of strong GLP-1 appetite suppression with meaningful GIP-mediated metabolic improvement creates a synergistic effect that exceeds what either receptor could produce alone, a principle similar to why peptide stacking sometimes outperforms individual compounds

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Consistent with this, we demonstrated that KU-57788 dose-dependently upregulates NRF2 mRNA and protein levels (Fig