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10.1016/j.jpha.2020.12.003 47 DattaS.GhoshS.BishayeeA.SinhaD

Interdisciplinary Toxicology

ORAL presentation at 27th Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2019), to be held in Madison, Wisconsin on July 7 11, 2019

Here, we dissect the importance of the MAS in cytosolic redox control versus aspartate production by generating cancer cell models lacking both GOT1 and GOT2, thereby simultaneously blocking canonical as-partate synthesis and MAS-mediated redox maintenance