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Compared with that in Keap1-wild-type cells, the total mitochondrial NADH pool in Keap1-KO cells was significantly increased, and it was significantly decreased in Nrf2-KO cells [119]

She underwent thrombectomy

[24] Chromosomal translocations of FOXO4 have been shown to be a cause of acute leukemia

While these results are broadly in line with the previously reported role of activated KRAS in supporting de novo serine synthesis 17 , it is clear that other genetic alterations such as amplification of PHGDH in MDA-MB-468 cells 14 also contribute to the dependence of cancer cells on a supply of exogenous serine